Channel monitored channel duplexer for optimization of bidirectional passive optical network

Method of optimizing the optical network transmission in access network has been investigated in many years. Unidirectional optical transmission system is the earliest method of delivering the information. In recent years, bidirectional optical transmission system is the most popular network and shall be the first right of refusal to deploy nowadays. It is justify enough by the massive deployment of the popular state-of-the-art network named Passive Optical Network (PON) in Fiber To The Home (FTTH) technologies. Combining 3 wavelengths includes (1) 1310nm, (2) 1490nm, and (3) 1550nm within a fiber is the method used on Gigabit Capable Passive Optical Network (GPON) or Gigabit Ethernet Passive Optical Network (GEPON/EPON). Combining 2 different wavelengths for uplink and downlink on Small Form Pluggable (SFP) lasers also has been a method used to optimized and saved the fiber infrastructure. Compared those techniques, the research optimization focusing on introducing a passive optical duplexer that combined the same wavelength from both end with the element of monitoring via different wavelength to confirm the network availability. In the design, a unidirectional converter able to operate at a nominal 1310nm or 1550nm windows shall be demonstrated up to 10Gbps Ethernet signal

Periduodenal Tuberculosis masquerading as Annular Pancreas

Gastrointestinal tuberculosis is common in Africa. Nonetheless, isolated  duodenal involvement is rare, and is more likely to mimic other causes of duodenal obstruction. We report a patient who succumbed to an isolated mid duodenal tuberculosis, diagnosed at laparatomy, whose clinical presentation, endoscopy and computerised tomography scans resembled annular pancreas. The limitations of clinical evaluation, endoscopy and radiology are highlighted as the importance of diagnostic laparoscopy is emphasized

Urban sprawl and its impact on sustainable urban development: a combination of remote sensing and social media data

Urbanization is one of the most impactful human activities across the world today affecting the quality of urban life and its sustainable development. Urbanization in Africa is occurring at an unprecedented rate and it threatens the attainment of Sustainable Development Goals (SDGs). Urban sprawl has resulted in unsustainable urban development patterns from social, environmental, and economic perspectives. This study is among the first examples of research in Africa to combine remote sensing data with social media data to determine urban sprawl from 2011 to 2017 in Morogoro urban municipality, Tanzania. Random Forest (RF) method was applied to accomplish imagery classification and location-based social media (Twitter usage) data were obtained through a Twitter Application Programming Interface (API). Morogoro urban municipality was classified into built-up, vegetation, agriculture, and water land cover classes while the classification results were validated by the generation of 480 random points. Using the Kernel function, the study measured the location of Twitter users within a 1 km buffer from the center of the city. The results indicate that, expansion of the city (built-up land use), which is primarily driven by population expansion, has negative impacts on ecosystem services because pristine grasslands and forests which provide essential ecosystem services such as carbon sequestration and support for biodiversity have been replaced by built-up land cover. In addition, social media usage data suggest that there is the concentration of Twitter usage within the city center while Twitter usage declines away from the city center with significant spatial and numerical increase in Twitter usage in the study area. The outcome of the study suggests that the combination of remote sensing, social sensing, and population data were useful as a proxy/inference for interpreting urban sprawl and status of access to urban services and infrastructure in Morogoro, and Africa city where data for urban planning is often unavailable, inaccurate, or stale

Reserpine-Induced Reduction in Norepinephrine Transporter Function Requires Catecholamine Storage Vesicles

Treatment of rats with reserpine, an inhibitor of the vesicular monoamine transporter (VMAT), depletes norepinephrine (NE) and regulates NE transporter (NET) expression. The present study examined the molecular mechanisms involved in regulation of the NET by reserpine using cultured cells. Exposure of rat PC12 cells to reserpine for a period as short as 5min decreased [ H]NE uptake capacity, an effect characterized by a robust decrease in the V of the transport of [ H]NE. As expected, reserpine did not displace the binding of [ H]nisoxetine from the NET in membrane homogenates. The potency of reserpine for reducing [ H]NE uptake was dramatically lower in SK-N-SH cells that have reduced storage capacity for catecholamines. Reserpine had no effect on [ H]NE uptake in HEK-293 cells transfected with the rat NET (293-hNET), cells that lack catecholamine storage vesicles. NET regulation by reserpine was independent of trafficking of the NET from the cell surface. Pre-exposure of cells to inhibitors of several intracellular signaling cascades known to regulate the NET, including Ca /Ca -calmodulin dependent kinase and protein kinases A, C and G, did not affect the ability of reserpine to reduce [ H]NE uptake. Treatment of PC12 cells with the catecholamine depleting agent, α-methyl-p-tyrosine, increased [ H]NE uptake and eliminated the inhibitory effects of reserpine on [ H]NE uptake. Reserpine non-competitively inhibits NET activity through a Ca -independent process that requires catecholamine storage vesicles, revealing a novel pharmacological method to modify NET function. Further characterization of the molecular nature of reserpine\u27s action could lead to the development of alternative therapeutic strategies for treating disorders known to be benefitted by treatment with traditional competitive NET inhibitors

The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts

Bone homeostasis is maintained by the balance between bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation in the activity of the bone cells can lead to osteoporosis, a disease characterized by low bone mass and an increase in bone fragility and risk of fracture. Kalirin is a novel GTP-exchange factor protein that has been shown to play a role in cytoskeletal remodeling and dendritic spine formation in neurons. We examined Kalirin expression in skeletal tissue and found that it was expressed in osteoclasts and osteoblasts. Furthermore, micro-CT analyses of the distal femur of global Kalirin knockout (Kal-KO) mice revealed significantly reduced trabecular and cortical bone parameters in Kal-KO mice, compared to WT mice, with significantly reduced bone mass in 8, 14 and 36 week-old female Kal-KO mice. Male mice also exhibited a decrease in bone parameters but not to the level seen in female mice. Histomorphometric analyses also revealed decreased bone formation rate in 14 week-old female Kal-KO mice, as well as decreased osteoblast number/bone surface and increased osteoclast surface/bone surface. Consistent with our in vivo findings, the bone resorbing activity and differentiation of Kal-KO osteoclasts was increased in vitro. Although alkaline phosphatase activity by Kal-KO osteoblasts was increased in vitro, Kal-KO osteoblasts showed decreased mineralizing activity, as well as decreased secretion of OPG, which was inversely correlated with ERK activity. Taken together, our findings suggest that deletion of Kalirin directly affects osteoclast and osteoblast activity, leading to decreased OPG secretion by osteoblasts which is likely to alter the RANKL/OPG ratio and promote osteoclastogenesis. Therefore, Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass

Children's daily travel to school in Johannesburg-Soweto, South Africa: geography and school choice in the Birth to Twenty cohort study

This paper has two aims: to explore approaches to the measurement of children’s daily travel to school in a context of limited geospatial data availability, and to provide data regarding school choice and distance travelled to school in Soweto-Johannesburg, South Africa. The paper makes use of data from the Birth to Twenty cohort study (n=1428) to explore three different approaches to estimating school choice and travel to school. Firstly, straight-line distance between home and school is calculated. Secondly, census geography is used to determine whether a child's home and school fall in the same area. Thirdly, distance data are used to determine whether a child attends the nearest school. Each of these approaches highlights a different aspect of mobility, and all provide valuable data. Overall, primary school aged children in Soweto-Johannesburg are shown to be travelling substantial distances to school on a daily basis. Over a third travel more than 3km, one-way, to school, 60% attend schools outside of the suburb in which they live, and only 18% attend their nearest school. These data provide evidence for high levels of school choice in Johannesburg-Soweto, and that families and children are making substantial investments in pursuit of high quality educational opportunities. Additionally, these data suggest that two patterns of school choice are evident: one pattern involving travel of substantial distances and requiring a higher level of financial investment, and a second pattern, involving choice between more local schools, requiring less travel and a more limited financial investment

Necessary fictions: indigenous claims and the humanity of rights

Indigenous right insistently challenges the surpassing arrogations of sovereign right. In so doing, it affirms dimensions of being-together denied or stunted in sovereign modes of political formation. This force of Indigenous right is amplified here through legal and literary instantiations. These, in turn, uncover the continuously created and fictional quality of rights, revealing them to be necessary fictions

Heritability of Attractiveness to Mosquitoes

Female mosquitoes display preferences for certain individuals over others, which is determined by differences in volatile chemicals produced by the human body and detected by mosquitoes. Body odour can be controlled genetically but the existence of a genetic basis for differential attraction to insects has never been formally demonstrated. This study investigated heritability of attractiveness to mosquitoes by evaluating the response of Aedes aegypti (=Stegomyia aegypti) mosquitoes to odours from the hands of identical and non-identical twins in a dual-choice assay. Volatiles from individuals in an identical twin pair showed a high correlation in attractiveness to mosquitoes, while non-identical twin pairs showed a significantly lower correlation. Overall, there was a strong narrow-sense heritability of 0.62 (SE 0.124) for relative attraction and 0.67 (0.354) for flight activity based on the average of ten measurements. The results demonstrate an underlying genetic component detectable by mosquitoes through olfaction. Understanding the genetic basis for attractiveness could create a more informed approach to repellent development